Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 9/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627699 | 0.90 | DPP4 (0.46) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL6638863 | 0.89 | DPP4 (0.53) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL1344707 | 0.86 | IDH1 (0.43) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL2638951 | 0.83 | DPP7 (0.47) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL3049238 | 0.83 | HCAR3 (0.51) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL1726095 | 0.83 | DPP7 (0.50) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL2638953 | 0.83 | DPP7 (0.47) | DPP7DPP4DPP8GSK3BIDH1 | |
| SCHEMBL1119557 | 0.83 | DPP7 (0.50) | DPP7DPP4DPP8GSK3BIDH1 | |
| Hydrochloric Acid SCHEMBL1119507 | 0.81 | DPP7 (0.49) | DPP7DPP4DPP8GSK3BIDH1 | |
| Hydrochloric Acid SCHEMBL1960447 | 0.81 | DPP7 (0.49) | DPP7DPP4DPP8GSK3BIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688573-A | Pyrrole based inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2005-10-26 | — | — | CN | disclosed |
| EP-0937040-A2 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | Novartis AG (CH) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998019998-A2 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | NOVARTIS AG (CH) | 1998-05-14 | — | — | WO | disclosed |