Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.59 |
| ▸ | PDE4A | P27815 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362818 | 0.85 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL30745160 | 0.83 | XDH (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL29151059 | 0.83 | XDH (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10782022 | 0.82 | LMNA (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10965403 | 0.81 | CYP1A2 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL3159466 | 0.79 | CYP1A2 (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10353459 | 0.79 | CYP1A2 (0.74) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL31178289 | 0.79 | DRD1 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL2088520 | 0.78 | MAP4K4 (0.50) | PDE4BTP53SMN1; SMN2DRD1MAP4K4 | |
| SCHEMBL14152213 | 0.78 | TP53 (0.61) | TP53SMN1; SMN2MAPTPLK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665074-A | CARDIOTONIC, BRONCHOSPASMOLYTIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-05-12 | — | — | US | disclosed |
| EP-0163965-A2 | Pyridazinones, their preparation and use, medicaments containing pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-12-11 | — | — | EP | disclosed |