Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600574 | 0.85 | NR4A1 (0.64) | GUSBEGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL958582 | 0.82 | EGFR (0.69) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL6811506 | 0.82 | EGFR (0.69) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL1557011 | 0.82 | FFAR1 (0.71) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL6760987 | 0.82 | GUSB (0.57) | GUSBEGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL4152328 | 0.81 | EGFR (0.72) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL27517502 | 0.81 | EGFR (0.68) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL11290489 | 0.79 | EGFR (0.66) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL6283205 | 0.79 | EGFR (0.70) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL8930320 | 0.79 | PARP10 (0.69) | EGFRNR4A1NR4A2NR4A3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952321-A | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0666846-A4 | — | — | 1995-09-20 | — | — | EP | disclosed |
| EP-0666846-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010143-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |