Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | TPMT | P51580 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.54 |
| ▸ | TUBB | P07437 | 6/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368574 | 0.91 | TUBB4A (0.57) | TTRTPMTTUBB4ATUBBTUBA3C | |
| SCHEMBL7785665 | 0.90 | TUBB4A (0.73) | TTRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7785541 | 0.89 | TTR (0.59) | TTRTPMTTUBB4ATUBBTUBA3C | |
| SCHEMBL29493652 | 0.88 | TPMT (0.74) | TTRTPMTMEN1KMT2AABCB1 | |
| SCHEMBL7370467 | 0.88 | TPMT (0.56) | TTRTPMTMEN1KMT2AABCB1 | |
| SCHEMBL1447399 | 0.88 | TPMT (0.74) | TTRTPMTMEN1KMT2AABCB1 | |
| SCHEMBL4818707 | 0.88 | TUBB4A (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8462586 | 0.87 | TPMT (0.59) | TPMTMEN1KMT2AABCB1ABCC1 | |
| SCHEMBL7373096 | 0.87 | TSHR (0.59) | TPMTMEN1KMT2AABCB1ABCC1 | |
| SCHEMBL1447496 | 0.87 | TPMT (0.55) | TTRTPMTTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705703-A | ENZYME INHIBITORS OF TRANSFERASES | HOFFMANN-LA ROCHE INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5633371-A | ENZYME INHIBITORS; TREATMENT OF DEPRESSION AND PARKINSON*S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5389653-A | Inhibitors of the enzyme catechol-O-methyltransferase; useful as co-medication in treatment of Parkinson's disease | HOFFMAN-LA ROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5236952-A | Inhibit the enzyme catechol-O-methyltransferase; for treatment of Parkinson's disease administered with L-dopa | HOFFMANN-LA ROCHE INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0237929-B1 | 3,5-DISUBSTITUTED PYROCATECHOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-02 | — | — | EP | disclosed |
| EP-0237929-A1 | 3,5-Disubstituted pyrocatechol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-23 | — | — | EP | disclosed |