Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.73 |
| ▸ | TUBB | P07437 | 3/20 | 0.73 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.73 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.73 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.73 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.73 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.73 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.73 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.73 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.73 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.73 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.73 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.73 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.73 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368386 | 0.90 | TTR (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7785541 | 0.88 | TTR (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7371341 | 0.88 | TTR (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7368574 | 0.87 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9189645 | 0.85 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4818707 | 0.84 | TUBB4A (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7367943 | 0.84 | TTR (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4824442 | 0.83 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL31337892 | 0.83 | TTR (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4821171 | 0.81 | TUBB1 (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |