Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.74 |
| ▸ | MME | P08473 | 1/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371290 | 1.00 | MMEL1 (0.74) | MMEL1MMEACE | |
| SCHEMBL7371286 | 1.00 | MMEL1 (0.74) | MMEL1MMEACE | |
| SCHEMBL7318461 | 0.92 | ACE (0.70) | MMEL1MMEACE | |
| SCHEMBL7367811 | 0.92 | ACE (0.70) | MMEL1MMEACE | |
| SCHEMBL7367809 | 0.92 | ACE (0.70) | MMEL1MMEACE | |
| SCHEMBL10791111 | 0.91 | ACE (0.68) | MMEL1MMEACE | |
| SCHEMBL10789074 | 0.91 | ACE (0.68) | MMEL1MMEACE | |
| SCHEMBL8861591 | 0.87 | MME (0.60) | MMEL1MMEACE | |
| SCHEMBL7367705 | 0.86 | ACE (0.54) | MMEL1MMEACE | |
| SCHEMBL7361926 | 0.86 | ACE (0.54) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | claimed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | claimed |
| CN-107257785-B | (2S,4R) -5- (5 '-chloro-2' -fluorobiphenyl-4-yl) -4- (ethoxyoxalylamino) -2-hydroxymethyl-2-methylpentanoic acid as enkephalinase inhibitors | 施万生物制药研发IP有限责任公司 | 2020-07-07 | — | — | CN | disclosed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |