Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.51 |
| ▸ | MMP2 | P08253 | 5/20 | 0.51 |
| ▸ | PLAU | P00749 | 9/20 | 0.49 |
| ▸ | PLG | P00747 | 4/20 | 0.49 |
| ▸ | PLAT | P00750 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6433466 | 0.95 | MMP9 (0.46) | MMP9MMP2PLAUPLGPLAT | |
| SCHEMBL6435308 | 0.89 | MMP2 (0.51) | MMP9MMP2PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL6439014 | 0.88 | MMP2 (0.50) | MMP9MMP2PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL6432557 | 0.88 | MMP2 (0.50) | MMP9MMP2PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL6436718 | 0.88 | PLAU (0.50) | PLAUPLGPLATRAB9A | |
| SCHEMBL6433554 | 0.87 | PLAU (0.45) | MMP9MMP2PLAUPLGPLAT | |
| SCHEMBL6433471 | 0.85 | PLAU (0.40) | MMP9MMP2PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL6433900 | 0.85 | PLAU (0.50) | PLAUPLGPLATRAB9A | |
| Hydrochloric Acid SCHEMBL6437300 | 0.82 | PLAU (0.68) | PLAUPLGPLATADAMTS4 | |
| Trifluoroacetic Acid SCHEMBL6432939 | 0.82 | F2 (0.47) | MMP9MMP2PLAUPLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |