Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | NMUR2 | Q9GZQ4 | 4/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423153 | 0.84 | NMUR2 (0.54) | NTRK1PLK3CYP3A4KDM4EHSD17B10 | |
| SCHEMBL1534666 | 0.79 | KMT2A (0.65) | NTRK1PLK3CYP3A4KDM4EHSD17B10 | |
| SCHEMBL29501080 | 0.79 | KMT2A (0.65) | NTRK1PLK3CYP3A4KDM4EHSD17B10 | |
| SCHEMBL10514551 | 0.77 | NMUR2 (0.53) | NTRK1PLK3CYP3A4KDM4EHSD17B10 | |
| SCHEMBL28381107 | 0.73 | MAOA (0.51) | NTRK1PLK3CYP3A4KDM4EHSD17B10 | |
| SCHEMBL6978811 | 0.73 | PTGS1 (0.59) | CYP3A4KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL13978680 | 0.72 | MAOA (0.57) | CYP3A4KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL21585300 | 0.72 | MAOA (0.63) | CYP3A4KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL6977307 | 0.71 | KDM4E (0.55) | CYP3A4KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3267918 | 0.70 | MAOA (0.64) | CYP3A4KDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714296-B1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | UNIV STRATHCLYDE (GB) | 2001-11-07 | — | — | EP | disclosed |
| EP-0973516-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | University of Strathclyde (GB) | 2000-01-26 | — | — | EP | disclosed |
| US-6004998-A | FLAVONOID 6,8-DIBROMOCHRYSIN | UNIVERSITY OF STRATHCLYDE (GB) | 1999-12-21 | — | — | US | disclosed |
| WO-1998044920-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | UNIVERSITY OF STRATHCLYDE (GB) | 1998-10-15 | — | — | WO | disclosed |
| US-5756538-A | REDUCING THE SEDATIVE AND RELAXANT SIDE EFFECT | UNIVERSITY OF STRATHCLYDE (GB) | 1998-05-26 | — | — | US | disclosed |
| EP-0714296-A1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | UNIVERSITY OF STRATHCLYDE (GB) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005169-A1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | THE UNIVERSITY OF STRATHCLYDE (GB) | 1995-02-23 | — | — | WO | disclosed |