Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379172 | 0.89 | SLC6A2 (0.41) | ACHELMNASMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL7375682 | 0.77 | MEN1 (0.50) | MEN1KMT2AACHELMNASMN1; SMN2 | |
| SCHEMBL5369143 | 0.77 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL5365936 | 0.76 | DRD2 (0.47) | MEN1KMT2AACHELMNASMN1; SMN2 | |
| SCHEMBL5365942 | 0.76 | MEN1 (0.50) | MEN1KMT2AACHEMAPK14CYP2C9 | |
| SCHEMBL5205297 | 0.75 | MEN1 (0.52) | MEN1KMT2AMAPK14CYP2C9CYP2C19 | |
| SCHEMBL1079888 | 0.73 | MAPK14 (0.63) | MEN1KMT2AACHELMNASMN1; SMN2 | |
| SCHEMBL20883165 | 0.69 | MAPK14 (0.61) | MEN1KMT2AMAPK14CYP2C9CYP2C19 | |
| SCHEMBL3492151 | 0.68 | MAPK14 (0.68) | MEN1KMT2AMAPK14CYP2C9CYP2C19 | |
| SCHEMBL5206748 | 0.68 | MAPK14 (0.50) | MEN1KMT2AMAPK14CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |