Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201673 | 0.82 | MEN1 (0.59) | MEN1KMT2AACHEBACE1CYP2C9 | |
| SCHEMBL7369230 | 0.77 | MEN1 (0.47) | MEN1KMT2AACHEBACE1DRD2 | |
| SCHEMBL7373279 | 0.74 | SLC6A2 (0.51) | MEN1KMT2A | |
| SCHEMBL5372928 | 0.74 | MAPK14 (0.48) | MEN1KMT2AHTR4CYP2C9 | |
| SCHEMBL5365936 | 0.74 | DRD2 (0.47) | MEN1KMT2AACHEDRD2DRD4 | |
| SCHEMBL20883165 | 0.72 | MAPK14 (0.61) | MEN1KMT2ACYP2C9 | |
| SCHEMBL30301407 | 0.71 | ACHE (0.75) | MEN1KMT2AACHEBACE1LMNA | |
| SCHEMBL27014556 | 0.71 | ACHE (0.75) | MEN1KMT2AACHEBACE1LMNA | |
| SCHEMBL5374207 | 0.71 | GPR84 (0.52) | MEN1KMT2AHTR2BALDH1A1SMN1; SMN2 | |
| SCHEMBL1079888 | 0.70 | MAPK14 (0.63) | MEN1KMT2AACHELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |