Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.50 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31084656 | 0.82 | MAPT (0.72) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| SCHEMBL3134094 | 0.82 | MAPT (0.72) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| Bromide SCHEMBL7368429 | 0.82 | MAPT (0.54) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| SCHEMBL7366431 | 0.79 | LARS1 (0.57) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| SCHEMBL6199409 | 0.79 | ALDH1A1 (0.57) | MAPTNPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL27428414 | 0.73 | ALDH1A1 (0.59) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| SCHEMBL7363044 | 0.73 | ALDH1A1 (0.59) | MAPTNPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL7374010 | 0.72 | MAPT (0.66) | MAPTNPC1SMN1; SMN2RAB9ARECQL | |
| SCHEMBL7367333 | 0.72 | MAPT (0.49) | MAPTNPC1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL25239669 | 0.71 | MAPT (0.81) | MAPTNPC1SMN1; SMN2RAB9ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705703-A | ENZYME INHIBITORS OF TRANSFERASES | HOFFMANN-LA ROCHE INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5633371-A | ENZYME INHIBITORS; TREATMENT OF DEPRESSION AND PARKINSON*S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5476875-A | Catechol derivatives | HOFFMAN-LA ROCHE INC. (US) | 1995-12-19 | — | — | US | disclosed |
| US-5389653-A | Inhibitors of the enzyme catechol-O-methyltransferase; useful as co-medication in treatment of Parkinson's disease | HOFFMAN-LA ROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5236952-A | Inhibit the enzyme catechol-O-methyltransferase; for treatment of Parkinson's disease administered with L-dopa | HOFFMANN-LA ROCHE INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0237929-B1 | 3,5-DISUBSTITUTED PYROCATECHOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-02 | — | — | EP | disclosed |
| EP-0237929-A1 | 3,5-Disubstituted pyrocatechol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-23 | — | — | EP | disclosed |