Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22162521 | 0.86 | MAPT (0.56) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2977328 | 0.86 | RAB9A (0.65) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2977331 | 0.86 | RAB9A (0.65) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL6198859 | 0.85 | KAT2B (0.80) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8288907 | 0.81 | RAB9A (0.60) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL29655446 | 0.81 | NPC1 (0.59) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2982740 | 0.81 | NPC1 (0.59) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL12515298 | 0.81 | KAT2B (0.69) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL906276 | 0.80 | RECQL (0.51) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL906299 | 0.80 | RECQL (0.54) | NPC1RAB9AMAPTSMN1; SMN2KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |