Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 5/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 3/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18507057 | 0.90 | DRD3 (0.70) | DRD3DRD2DRD4SLC6A2SLC6A4 | |
| SCHEMBL10724020 | 0.89 | MAPT (0.75) | ALDH1A1DRD3DRD2POLBSLC6A2 | |
| SCHEMBL7369877 | 0.88 | DRD3 (0.77) | KDM4EALDH1A1DRD3DRD2POLB | |
| SCHEMBL4521840 | 0.86 | DRD4 (0.77) | DRD3DRD2DRD4 | |
| SCHEMBL7371815 | 0.85 | DRD2 (0.84) | DRD3DRD2POLBDRD4SLC6A4 | |
| SCHEMBL31061220 | 0.84 | DRD3 (0.84) | DRD3DRD2POLBDRD4 | |
| SCHEMBL10826820 | 0.84 | DRD2 (0.68) | DRD3DRD2POLBSLC6A2SLC6A4 | |
| SCHEMBL10379079 | 0.83 | CYP2C9 (0.73) | KDM4EALDH1A1POLB | |
| SCHEMBL3124560 | 0.83 | POLB (0.81) | ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL2355678 | 0.80 | DRD3 (0.72) | DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714292-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-10-09 | — | — | EP | claimed |
| EP-0714292-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995000131-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) | 1995-01-05 | — | — | WO | claimed |