Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.72 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.72 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.72 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.72 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.72 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.72 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374142 | 1.00 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL27550290 | 0.87 | AKR1C3 (0.86) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7369162 | 0.86 | HDAC1 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7370548 | 0.86 | HDAC1 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7374708 | 0.85 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7369960 | 0.85 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL19837643 | 0.85 | DRD2 (0.90) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL19837655 | 0.85 | DRD2 (0.90) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL6473590 | 0.85 | AKR1C3 (0.78) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL6481222 | 0.85 | AKR1C3 (0.78) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133104-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2015-09-15 | — | — | US | disclosed |
| US-20140163042-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2014-06-12 | — | — | US | disclosed |
| US-20130116318-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2013-05-09 | — | — | US | disclosed |
| US-20020177594-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-11-28 | — | — | US | disclosed |
| US-20020103192-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-08-01 | — | — | US | disclosed |
| WO-2002046129-A2 | INHIBITORS OF HISTONE DEACETYLASE | ABBOTT LABORATORIES (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103192-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC4 | HDAC1 1/4885HDAC2 7/4885HDAC3 6/4885 |
| US-20130116318-A1 | Enzyme Inhibitors | HDAC1, HDAC11, HDAC7 | HDAC1 1/4885HDAC2 4/4885HDAC3 7/4885 |
| US-20020177594-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC2 4/4885HDAC3 3/4885 |
| US-20140163042-A1 | ENZYME INHIBITORS | HAT1, NR2E1, HDAC3 | HDAC1 5/4885HDAC2 31/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.