Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.82 |
| ▸ | RAB9A | P51151 | 6/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.71 |
| ▸ | CLK2 | P49760 | 1/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.71 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | F2 | P00734 | 1/20 | 0.70 |
| ▸ | MAOB | P27338 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169511 | 0.90 | NPC1 (0.68) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL15764664 | 0.90 | NPC1 (1.00) | NPC1RAB9AMAP4K4CLK2DYRK1A | |
| SCHEMBL5415418 | 0.85 | NPC1 (0.86) | NPC1RAB9AMAP4K4CLK2DYRK1A | |
| SCHEMBL29429758 | 0.83 | RAB9A (0.80) | NPC1RAB9AKDM4ESMN1; SMN2MAP4K4 | |
| SCHEMBL3378320 | 0.83 | RAB9A (0.80) | NPC1RAB9AKDM4ESMN1; SMN2MAP4K4 | |
| Hydrochloric Acid SCHEMBL7368705 | 0.82 | RAB9A (0.78) | NPC1RAB9AKDM4ESMN1; SMN2MAP4K4 | |
| SCHEMBL11509146 | 0.80 | NPC1 (0.64) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL11509143 | 0.80 | NPC1 (0.64) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL7337800 | 0.79 | MAP4K4 (0.66) | MAP4K4CLK2DYRK1ASRPK1CLK4 | |
| SCHEMBL6170427 | 0.79 | NPC1 (0.70) | NPC1RAB9AKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019045-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1019045-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999000128-A9 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 1999-08-05 | — | — | WO | disclosed |
| WO-1999000128-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | WO | disclosed |