Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 3/20 | 0.31 |
| ▸ | CDK8 | P49336 | 3/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 2/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.30 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.30 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374768 | 0.92 | CHUK (0.37) | CHUKAAK1CCNCCDK8HASPIN | |
| SCHEMBL7373225 | 0.89 | CCNC (0.32) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7377524 | 0.85 | WEE1 (0.37) | AAK1FGFR1CCNCCDK8HASPIN | |
| SCHEMBL7290178 | 0.84 | CYP11B2 (0.32) | KDM4EFGFR1CCNCCDK8HASPIN | |
| SCHEMBL7296855 | 0.83 | SMN1; SMN2 (0.34) | AAK1KDM4EHSD17B10FGFR1CCNC | |
| SCHEMBL7293801 | 0.82 | AURKA (0.32) | KDM4ECCNCCDK8HASPINCDK19 | |
| SCHEMBL8084419 | 0.81 | CFTR (0.38) | FGFR1SRC | |
| SCHEMBL8088696 | 0.81 | PDE4A (0.37) | KDM4E | |
| SCHEMBL7372821 | 0.81 | S100A4 (0.36) | PTK2 | |
| SCHEMBL7371406 | 0.81 | CCNC (0.37) | AAK1CCNCCDK8HASPINCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |