Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.51 |
| ▸ | CA1 | P00915 | 7/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 6/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6434979 | 0.94 | CA2 (0.46) | CA2CA1CASP3ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL6434983 | 0.94 | CA2 (0.46) | CA2CA1CASP3ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL6434379 | 0.85 | CA2 (0.46) | CA2CA1TMPRSS15GRNSORT1 | |
| SCHEMBL7369537 | 0.85 | CTSA (0.46) | ITGB3ITGA2B | |
| SCHEMBL7401273 | 0.84 | CA2 (0.55) | CA2CA1CASP3TMPRSS15GRN | |
| SCHEMBL7401270 | 0.84 | CA2 (0.55) | CA2CA1CASP3TMPRSS15GRN | |
| SCHEMBL6434387 | 0.83 | MRGPRX4 (0.37) | CA2CA1TMPRSS15GRNSORT1 | |
| Trifluoroacetic Acid SCHEMBL6432685 | 0.83 | CA2 (0.49) | CA2CA1 | |
| Trifluoroacetic Acid SCHEMBL6435197 | 0.83 | GRN (0.51) | CA2CA1ITGB3ITGA2BTMPRSS15 | |
| Trifluoroacetic Acid SCHEMBL6432682 | 0.83 | CA2 (0.49) | CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |