Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HTR2C | P28335 | 10/20 | 0.62 |
| ▸ | HTR2B | P41595 | 9/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7664488 | 0.99 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| SCHEMBL7407429 | 0.91 | HTR2C (0.68) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7657879 | 0.90 | HTR2C (0.67) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| SCHEMBL27579461 | 0.79 | PLK4 (0.73) | SMN1; SMN2HTR2CHTR2BPLK4CHEK1 | |
| SCHEMBL3807061 | 0.78 | HTR2C (0.73) | HTR2CHTR2BPLK4CHEK1PDPK1 | |
| SCHEMBL7369475 | 0.78 | HTR2C (0.75) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| SCHEMBL7452301 | 0.77 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| SCHEMBL7369937 | 0.76 | HTR2C (0.70) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7657158 | 0.76 | HTR2C (0.58) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7656183 | 0.76 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |