Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.75 |
| ▸ | HTR2B | P41595 | 8/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375350 | 0.89 | HTR2C (0.74) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL7654391 | 0.86 | HTR2C (0.67) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL7369937 | 0.85 | HTR2C (0.70) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL10436769 | 0.85 | HTR2C (0.56) | HTR2CHTR2BMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7664592 | 0.85 | HTR2C (0.98) | HTR2CHTR2BMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7657712 | 0.85 | HTR2C (0.69) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL7371124 | 0.85 | FADS1 (0.67) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL27579461 | 0.83 | PLK4 (0.73) | HTR2CHTR2BMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7654414 | 0.83 | HTR2C (0.63) | HTR2CHTR2BMEN1NPC1RAB9A | |
| SCHEMBL7372365 | 0.82 | PABPC1 (0.61) | HTR2CHTR2BMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |