Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.59 |
| ▸ | PDE4A | P27815 | 6/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370364 | 0.95 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7368562 | 0.93 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7360467 | 0.87 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7360489 | 0.84 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7365058 | 0.83 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7367735 | 0.80 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1572501 | 0.77 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29504585 | 0.77 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6745558 | 0.77 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9158097 | 0.76 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642489-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993007111-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |