Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.64 |
| ▸ | PDE4A | P27815 | 6/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29504585 | 1.00 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6745558 | 0.99 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| Lithium Ion SCHEMBL6745554 | 0.89 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6322653 | 0.84 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7368562 | 0.81 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7365058 | 0.79 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9167416 | 0.78 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5184039 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL15040911 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7370366 | 0.77 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176221-B1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | claimed |
| US-20090041722-A1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY | 2009-02-12 | — | — | US | claimed |
| US-20080292562-A1 | Medicaments For Inhalation Comprising Pde IV Inhibitors and Enantiomerically Pure Glycopyrrolate Salts | PIEPER MICHAEL P | 2008-11-27 | — | — | US | claimed |
| US-20040176419-A1 | Composition comprising a pde-4 inhibitor and h1-receptor antagonist and the use thereof for the manufacture of a medicament for the treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2004-09-09 | — | — | US | claimed |
| EP-1404369-A1 | COMPOSITION COMPRISING A PDE-4 INHIBITOR AND H1-RECEPTOR ANTAGONIST AND THE USE THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-04-07 | — | — | EP | claimed |
| WO-2003000289-A1 | COMPOSITION COMPRISING A PDE-4 INHIBITOR AND H1-RECEPTOR ANTAGONIST AND THE USE THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-01-03 | — | — | WO | claimed |
| US-7943658-B2 | Indole indane amide compounds useful as CB2 agonists and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2176221-B1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | disclosed |
| EP-2176221-A1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | Bristol-Myers Squibb Company (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009154562-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A 4-HYDROXY-2-OXO-2, 3- DIHYDRO-1, 3-BENZOTHIAZOL-7-YL COMPOUND FOR MODULATION OF BETA2-ADRENORECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
| US-20090264452-A1 | 2-(Phenylamino)-Pyrimidin-5-Amides As Cannabinoid 2 Receptors Modulators for the Treatment of Immune or Inflammatory Disorders | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | US | disclosed |
| US-20090041722-A1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY | 2009-02-12 | — | — | US | disclosed |
| WO-2009015169-A1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-29 | — | — | WO | disclosed |
| EP-1107747-A1 | THERAPIES FOR TREATING PULMONARY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-20 | — | — | EP | disclosed |
| US-6143782-A | BRONCHODILATOR FOR INHIBITING PDE IV CATALYSTS AND BINDING RROLIPRAM AND ADMINISTERING | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-07 | — | — | US | disclosed |
| WO-2000012078-A1 | THERAPIES FOR TREATING PULMONARY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-09 | — | — | WO | disclosed |
| US-5998428-A | ANTIINFLAMMATORY AGENT; SIDE EFFECT REDUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0710109-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0710109-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995000139-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176419-A1 | Composition comprising a pde-4 inhibitor and h1-receptor antagonist and the use thereof for the manufacture of a medicament for the treatment of respiratory diseases | PDE4A, PDE12, HRH4 | PDE4B 4/4885PDE4A 1/4885PDE4C 8/4885 |
| US-20090264452-A1 | 2-(Phenylamino)-Pyrimidin-5-Amides As Cannabinoid 2 Receptors Modulators for the Treatment of Immune or Inflammatory Disorders | CNR2, CNR1, P2RY2 | PDE4B 1013/4885PDE4A 1364/4885PDE4C 1209/4885 |
| US-20080292562-A1 | Medicaments For Inhalation Comprising Pde IV Inhibitors and Enantiomerically Pure Glycopyrrolate Salts | PDE3A, PDE3B, PDE12 | PDE4B 7/4885PDE4A 5/4885PDE4C 10/4885 |
| US-20090041722-A1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | CNR2, CNR1, GPR68 | PDE4B 1514/4885PDE4A 1262/4885PDE4C 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.