Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.58 |
| ▸ | F10 | P00742 | 3/20 | 0.58 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.54 |
| ▸ | PLAT | P00750 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419341 | 0.87 | F2 (0.60) | F2F10TMPRSS6PLATTPSAB1 | |
| SCHEMBL3057528 | 0.87 | F2 (0.60) | F2F10TMPRSS6PLATTPSAB1 | |
| SCHEMBL9189122 | 0.81 | PLG (0.67) | F2F10PLAUPRSS1 | |
| SCHEMBL29514928 | 0.81 | PLG (0.67) | F2F10PLAUPRSS1 | |
| SCHEMBL29651383 | 0.81 | PLG (0.67) | F2F10PLAUPRSS1 | |
| SCHEMBL8144360 | 0.81 | PLG (0.67) | F2F10PLAUPRSS1 | |
| SCHEMBL872422 | 0.81 | PLG (0.67) | F2F10PLAUPRSS1 | |
| Piperidine SCHEMBL7370685 | 0.80 | F2 (0.53) | F2F10TMPRSS6PLATKAT6A | |
| Hydrochloric Acid SCHEMBL7394320 | 0.78 | F2 (0.56) | F2F10TMPRSS6PLATCTSS | |
| SCHEMBL9664068 | 0.77 | F10 (0.71) | F2F10TMPRSS6PLATPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810858-A4 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | DU PONT PHARM CO (US) | 2000-11-15 | — | — | EP | disclosed |
| US-5731439-A | TRYPSIN-LIKE SERINE PROTEASE INGHBITORS, ANTICOAGULANTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5698538-A | Boronic acid and ester inhibitors of thrombin | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0810858-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5639739-A | USEFUL FOR TREATING THROMBOSIS IN MAMMALS BY INHIBITING TRYPSIN-LIKE SERINE PROTEASE ENZYMES | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| US-5563127-A | USEFUL TO TREAT THROMBOSIS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| WO-1996020689-A2 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-11 | — | — | WO | disclosed |
| WO-1994021650-A1 | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |