Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9427564 | 0.96 | MAPK14 (0.40) | MAPK14ADRB3NPC1RAB9ATRPC6 | |
| Fumaric Acid SCHEMBL9427555 | 0.96 | MAPK14 (0.40) | MAPK14ADRB3NPC1RAB9ATRPC6 | |
| SCHEMBL9427352 | 0.88 | NPC1 (0.42) | MAPK14ADRB3NPC1RAB9ATRPC6 | |
| Oxalic Acid SCHEMBL9427521 | 0.88 | KDM4E (0.41) | MAPK14ADRB3NPC1RAB9ATRPC6 | |
| SCHEMBL7343376 | 0.85 | SMN1; SMN2 (0.43) | MAPK14NPC1RAB9ATRPC6MAPT | |
| SCHEMBL7341049 | 0.85 | MAPK14 (0.43) | MAPK14NPC1RAB9ATRPC6MAPT | |
| SCHEMBL9427560 | 0.81 | ADRB3 (0.40) | ADRB3ADRB1SIGMAR1MEN1KMT2A | |
| SCHEMBL7343184 | 0.80 | KCNH2 (0.49) | NPC1RAB9ATRPC6MAPTSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9427500 | 0.80 | KDM4E (0.47) | TRPC6MAPTL3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL7350138 | 0.78 | MAPK14 (0.43) | MAPK14NPC1RAB9ATRPC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582506-B1 | Tetrahydronaphtalene derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1996-02-28 | — | — | EP | disclosed |
| EP-0582506-A1 | Tetrahydronaphtalene derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1994-02-09 | — | — | EP | disclosed |