Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9181996 | 0.86 | NSD2 (0.58) | HTR1AADRA1DADRA1AADRA1BNR4A2 | |
| SCHEMBL11428540 | 0.83 | NR4A2 (0.53) | HTR1AADRA1DADRA1AADRA1BNR4A2 | |
| SCHEMBL1337689 | 0.80 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BG6PD | |
| SCHEMBL30543156 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BNSD2 | |
| SCHEMBL2699726 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BNSD2 | |
| SCHEMBL7247375 | 0.79 | NSD2 (0.54) | HTR1AADRA1DADRA1AADRA1BNR4A2 | |
| SCHEMBL2178344 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BNR4A2 | |
| SCHEMBL4014412 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BNSD2 | |
| SCHEMBL31337072 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BNSD2 | |
| SCHEMBL24715854 | 0.78 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |
| US-4218369-A | FOR DYEING POLYACRYLONITRILE | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1980-08-19 | — | — | US | disclosed |