Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 18/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.52 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408154 | 0.93 | CTSS (0.54) | TACR2MMP9MMP8PSMB8PSMB9 | |
| SCHEMBL7398380 | 0.92 | CTSS (0.53) | TACR2PSMB8PSMB9PSMB5PSMB10 | |
| SCHEMBL7405180 | 0.92 | TACR2 (0.57) | TACR2MMP2MMP9MMP8PSMB11 | |
| SCHEMBL7344537 | 0.90 | TACR2 (0.64) | TACR2MMP2MMP9MMP8 | |
| SCHEMBL8193543 | 0.88 | TACR2 (0.62) | TACR2MMP2MMP9MMP8 | |
| SCHEMBL7345251 | 0.86 | TACR2 (0.60) | TACR2MMP2MMP9MMP8PSMB11 | |
| SCHEMBL7370096 | 0.86 | TACR2 (0.60) | TACR2MMP2MMP9MMP8PSMB11 | |
| SCHEMBL7401617 | 0.85 | TACR2 (0.58) | TACR2MMP2MMP9MMP8 | |
| SCHEMBL7446475 | 0.84 | CTSS (0.51) | TACR2PSMB8PSMB9PSMB5PSMB10 | |
| SCHEMBL7342593 | 0.84 | TACR2 (0.58) | TACR2PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |