Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 10/20 | 0.43 |
| ▸ | CASP6 | P55212 | 9/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL7370755 | 1.00 | TXNRD1 (0.43) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| SCHEMBL7111662 | 0.92 | TXNRD1 (0.45) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| Aspartic Acid SCHEMBL6801349 | 0.88 | CASP3 (0.42) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| Aspartic Acid SCHEMBL6801963 | 0.87 | CASP3 (0.46) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| SCHEMBL12946377 | 0.86 | CASP3 (0.49) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| Aspartic Acid SCHEMBL6801790 | 0.85 | CASP3 (0.46) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| Aspartic Acid SCHEMBL7370756 | 0.84 | GRIK1 (0.41) | TXNRD1CASP3CASP6CASP8L3MBTL1 | |
| Aspartic Acid SCHEMBL5445289 | 0.84 | SLC1A3 (0.39) | L3MBTL1KMT2ATDP1MEN1 | |
| Aspartic Acid SCHEMBL6800781 | 0.83 | CASP3 (0.48) | TXNRD1CASP3CASP6CASP8KMT2A | |
| Aspartic Acid SCHEMBL6802029 | 0.83 | CASP3 (0.46) | TXNRD1CASP3CASP6CASP8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764167-A4 | BICYCLING LACTAM INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME | SANOFI WINTHROP INC (US) | 1997-09-17 | — | — | EP | claimed |
| EP-0764167-A1 | BICYCLING LACTAM INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME | SANOFI WINTHROP, INC. (US) | 1997-03-26 | — | — | EP | claimed |
| WO-1995033751-A1 | BICYCLING LACTAM INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME | SANOFI WINTHROP, INC. (US) | 1995-12-14 | — | — | WO | claimed |