Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | HPN | P05981 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403061 | 0.87 | HPGD (0.43) | HPGDKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6437407 | 0.86 | PLAU (0.39) | HPGDKDM4EALDH1A1PLAUHPN | |
| SCHEMBL7367854 | 0.84 | PPARG (0.42) | HPGDLMNASMN1; SMN2PLAUPDE4A | |
| SCHEMBL7390699 | 0.81 | GAA (0.44) | RAB9A | |
| SCHEMBL6435509 | 0.81 | GRN (0.38) | HPGDALDH1A1SMN1; SMN2PDE4APDE4B | |
| Trifluoroacetic Acid SCHEMBL6435583 | 0.80 | PYGL (0.42) | PLAUHPNF10PRSS1CYP2C9 | |
| SCHEMBL7367423 | 0.80 | POLB (0.46) | KDM4EALDH1A1LMNAPDE4APDE4B | |
| SCHEMBL6433837 | 0.74 | PLAU (0.51) | KDM4EALDH1A1PLAUMAPT | |
| SCHEMBL7390695 | 0.74 | CYP1A2 (0.34) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL6437001 | 0.72 | NPR3 (0.41) | HPGDKDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |