Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 7/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378632 | 0.91 | AVPR2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7376623 | 0.87 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1B | |
| SCHEMBL7368727 | 0.86 | PPARD (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7368726 | 0.86 | PPARD (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7377221 | 0.85 | PPARD (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7377226 | 0.85 | PPARD (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7370821 | 0.83 | GAA (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7370827 | 0.83 | GAA (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7377003 | 0.81 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL7377924 | 0.80 | MEN1 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |