Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | CTRC | Q99895 | 1/20 | 0.53 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370909 | 1.00 | ERBB2 (0.57) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL8546141 | 0.84 | EGFR (0.54) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL8539935 | 0.84 | MAPT (0.57) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL8544253 | 0.84 | ERBB2 (0.54) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL7320051 | 0.83 | EGFR (0.53) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL7320047 | 0.83 | EGFR (0.53) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL7312445 | 0.82 | PLK4 (0.52) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL7312451 | 0.82 | PLK4 (0.52) | ERBB2EGFRIGF1RCTRCEEF2K | |
| SCHEMBL8539170 | 0.80 | CTRC (0.54) | ERBB2EGFRIGF1RMAPTAPP | |
| SCHEMBL8543090 | 0.80 | EGFR (0.50) | ERBB2EGFRIGF1RMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420428-B1 | TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-07-16 | — | — | US | disclosed |
| US-6369097-B1 | Treatment and prevention of hepatic disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-04-09 | — | — | US | disclosed |
| US-6348493-B1 | TREATMENT OF HEPATITIS C BY ADMINISTERING 2,6-DI-TER-BUTYLPHENOL | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-19 | — | — | US | disclosed |
| US-6218437-B1 | ADMINISTERING A THERAPEUTIC AMOUNT OF DI-TERT-BUTYLPHENOL DERIVATIVE TO SUBJECT UNDER CONDITIONS SUCH THAT SAID SYMPTOMS ARE DIMINISHED | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-04-17 | — | — | US | disclosed |
| WO-2001021166-A1 | TREATMENT AND PREVENTION OF HEPATIC DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-03-29 | — | — | WO | disclosed |
| US-5124347-A | Inhibits 5-lipoxygenase and cyclooxygenase; for treatment of allergies, arthritis, pain | WARNER-LAMBERT CO. (US) | 1992-06-23 | — | — | US | disclosed |