Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | EEF2K | O00418 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539007 | 0.89 | CTRC (0.48) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL8539935 | 0.84 | MAPT (0.57) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL8544308 | 0.83 | ERBB2 (0.49) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL8542369 | 0.83 | ERBB2 (0.48) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL8543090 | 0.80 | EGFR (0.50) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL7370909 | 0.80 | ERBB2 (0.57) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL7370906 | 0.80 | ERBB2 (0.57) | CTRCEGFRERBB2IGF1RSIRT1 | |
| SCHEMBL7672585 | 0.80 | APP (0.52) | ERBB2APPMAPTSNCAMEN1 | |
| SCHEMBL7672581 | 0.80 | APP (0.52) | ERBB2APPMAPTSNCAMEN1 | |
| SCHEMBL8544253 | 0.77 | ERBB2 (0.54) | CTRCEGFRERBB2IGF1RSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580502-B1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR (FR) | 1998-09-02 | — | — | EP | claimed |
| EP-0580502-A1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-01-26 | — | — | EP | claimed |