Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXM1 | Q08050 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346696 | 1.00 | FOXM1 (0.46) | FOXM1NPC1RAB9AMAOBAPP | |
| SCHEMBL1347012 | 0.89 | KDM1A (0.52) | FOXM1BCHELMNA | |
| SCHEMBL1346381 | 0.88 | ALDH1A1 (0.46) | MAOBAPPNR4A2 | |
| SCHEMBL1346938 | 0.88 | MEN1 (0.48) | NPC1RAB9AMAOBAPPBCHE | |
| SCHEMBL7378463 | 0.88 | ALDH1A1 (0.46) | MAOBAPPNR4A2 | |
| SCHEMBL1346559 | 0.88 | MAOB (0.50) | MAOBMAOAHTR6 | |
| SCHEMBL7377110 | 0.88 | MAOB (0.50) | MAOBMAOAHTR6 | |
| SCHEMBL1346274 | 0.87 | S1PR1 (0.47) | MAOBMAOAHTR6 | |
| SCHEMBL1346576 | 0.85 | SCN9A (0.49) | MAOBMAOA | |
| SCHEMBL1346471 | 0.84 | MEN1 (0.50) | RAB9AMAOBNR4A2LMNAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842152-B1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | NEWRON PHARM SPA (IT) | 2001-01-31 | — | — | EP | disclosed |
| EP-0842152-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005111-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-02-13 | — | — | WO | disclosed |