Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | APOL1 | O14791 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346381 | 1.00 | ALDH1A1 (0.46) | ALDH1A1APOL1PTPN1S1PR5MAOB | |
| SCHEMBL1346835 | 0.93 | ALDH1A1 (0.44) | ALDH1A1PTPN1S1PR5MAOBAPP | |
| SCHEMBL1344438 | 0.92 | PSEN1 (0.46) | ALDH1A1PTPN1S1PR5APPKCNH2 | |
| SCHEMBL1347012 | 0.89 | KDM1A (0.52) | APOL1KDM1A | |
| SCHEMBL1346696 | 0.88 | FOXM1 (0.46) | MAOBAPPNR4A2 | |
| SCHEMBL1346938 | 0.88 | MEN1 (0.48) | ALDH1A1MAOBAPP | |
| SCHEMBL7370997 | 0.88 | FOXM1 (0.46) | MAOBAPPNR4A2 | |
| SCHEMBL1346598 | 0.88 | MAOB (0.50) | MAOBKCNH2NR4A2 | |
| SCHEMBL1345209 | 0.88 | MAOB (0.50) | MAOBKCNH2NR4A2 | |
| SCHEMBL1346576 | 0.87 | SCN9A (0.49) | PTPN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842152-B1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | NEWRON PHARM SPA (IT) | 2001-01-31 | — | — | EP | disclosed |
| EP-0842152-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005111-A1 | N-(4-SUBSTITUTED-BENZYL)-2-AMINOLACTAM DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-02-13 | — | — | WO | disclosed |