Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11924989 | 0.82 | CA12 (0.57) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL29941410 | 0.82 | CA12 (0.57) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL27256571 | 0.79 | CA12 (0.53) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL1807118 | 0.79 | CA12 (0.53) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL5197627 | 0.79 | CA12 (0.53) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL6532204 | 0.74 | MEN1 (0.42) | BRD4MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL28399521 | 0.74 | CA12 (0.52) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL12330832 | 0.72 | KDM4E (0.54) | MEN1KMT2AHSD17B10KDM4ELMNA | |
| SCHEMBL11656873 | 0.71 | KMT2A (0.54) | MEN1KMT2AHSD17B10CYP2D6KDM4E | |
| SCHEMBL27900581 | 0.70 | MEN1 (0.49) | BRD4MEN1KMT2AHSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021824-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOL-2-ONE DERIVATIVES AS VOLTAGE GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD (GB) | 1995-08-17 | — | — | WO | claimed |
| WO-1995021823-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD. (GB) | 1995-08-17 | — | — | WO | disclosed |