Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 4/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 8/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378048 | 0.81 | AGTR1 (0.55) | PCSK9AGTR1HTR6PTGDR2PSEN1 | |
| SCHEMBL19605706 | 0.77 | HTR6 (0.50) | PCSK9AGTR1HTR6PTGDR2PTGDR | |
| SCHEMBL7192965 | 0.77 | AGTR1 (0.55) | PCSK9AGTR1HTR6 | |
| SCHEMBL9588666 | 0.76 | PCSK9 (0.48) | PCSK9AGTR1HTR6PSEN1PSEN2 | |
| SCHEMBL17521604 | 0.76 | PCSK9 (0.87) | PCSK9AGTR1HTR6 | |
| SCHEMBL4312597 | 0.75 | PSEN1 (0.49) | HTR6KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL12093313 | 0.73 | HTR6 (0.70) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496512 | 0.72 | AGTR1 (0.47) | PCSK9AGTR1HTR6 | |
| SCHEMBL17521607 | 0.72 | PCSK9 (0.58) | PCSK9AGTR1HTR6 | |
| SCHEMBL27885302 | 0.71 | HTR6 (0.50) | AGTR1HTR6PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420086-B1 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5256780-A | Serotonin antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| US-5180728-A | Antagonists of 5-hydroxytryptamine | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0420086-A2 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |