Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369883 | 0.91 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7370838 | 0.89 | MKNK1 (0.46) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7370568 | 0.88 | CYP3A4 (0.55) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7366043 | 0.87 | CYP11B1 (0.44) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7370764 | 0.86 | KDM4E (0.48) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7369586 | 0.86 | ROS1 (0.47) | CYP11B1CYP11B2CYP3A4NR1I2HSD11B1 | |
| SCHEMBL7374321 | 0.86 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7373136 | 0.85 | POLB (0.51) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7372273 | 0.85 | MKNK1 (0.43) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 | |
| SCHEMBL7371256 | 0.83 | MKNK1 (0.42) | CYP11B1CYP11B2CYP19A1CYP17A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |