Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | USP1 | O94782 | 1/20 | 0.42 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368774 | 0.89 | P2RX7 (0.50) | POLBFYNALDH1A1MEN1KMT2A | |
| SCHEMBL7372593 | 0.88 | DHFR (0.43) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL7370838 | 0.87 | MKNK1 (0.46) | MAPTPDE10APDE2APDE5APDE11A | |
| SCHEMBL7376110 | 0.87 | ADRA2A (0.45) | POLBFYNPDE5ACYP11B1CYP11B2 | |
| SCHEMBL7370764 | 0.86 | KDM4E (0.48) | POLBMAPTPDE10APDE2APDE5A | |
| SCHEMBL7365766 | 0.86 | APLNR (0.45) | POLBFYNALDH1A1MEN1KMT2A | |
| SCHEMBL7370568 | 0.86 | CYP3A4 (0.55) | NPSR1CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL7372635 | 0.86 | CYP11B2 (0.52) | ALDH1A1NPSR1PDE10APDE2APDE5A | |
| SCHEMBL28766867 | 0.85 | PTGS2 (0.43) | POLBFYNMEN1KMT2ACYP11B2 | |
| SCHEMBL7369883 | 0.85 | CYP11B1 (0.46) | POLBMEN1KMT2APDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |