Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | PDE2A | O00408 | 4/20 | 0.39 |
| ▸ | PDE5A | O76074 | 4/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370838 | 0.85 | MKNK1 (0.46) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7370568 | 0.84 | CYP3A4 (0.55) | MKNK1MKNK2CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL7372122 | 0.83 | CYP11B1 (0.46) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7370764 | 0.82 | KDM4E (0.48) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7373136 | 0.81 | POLB (0.51) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7372273 | 0.81 | MKNK1 (0.43) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7368423 | 0.81 | CYP19A1 (0.50) | MKNK1MKNK2CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL7371552 | 0.80 | CYP11B1 (0.49) | MKNK1MKNK2CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL7366043 | 0.79 | CYP11B1 (0.44) | MKNK1MKNK2PDE10APDE2APDE5A | |
| SCHEMBL7369440 | 0.78 | CYP11B1 (0.45) | MKNK1MKNK2PDE10APDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |