Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516239 | 0.87 | ACE (0.62) | POLBTACR1ACEMBTPS1CTSC | |
| SCHEMBL18429658 | 0.87 | ACE (0.62) | POLBTACR1ACEMBTPS1CTSC | |
| SCHEMBL18515876 | 0.87 | ACE (0.62) | POLBTACR1ACEMBTPS1CTSC | |
| SCHEMBL3394167 | 0.86 | CTSK (0.56) | CTSKALDH1A1 | |
| SCHEMBL3394165 | 0.86 | CTSK (0.56) | CTSKALDH1A1 | |
| SCHEMBL30516234 | 0.86 | CTSK (0.56) | CTSKALDH1A1 | |
| SCHEMBL28288517 | 0.86 | CTRB1 (0.51) | POLBTACR1ACEMBTPS1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11526166 | 0.86 | ACE (0.60) | POLBTACR1ACEMBTPS1CTSC | |
| Hydrochloric Acid SCHEMBL11604468 | 0.85 | CTSK (0.55) | CTSKALDH1A1 | |
| SCHEMBL26195471 | 0.84 | CTSK (0.64) | TACR1CTSKALDH1A1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810994-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5719162-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-02-17 | — | — | US | disclosed |
| US-5719144-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0810994-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5665723-A | PIPERAZINE ISOINDOLE DERIVATIVES | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1996026187-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |