Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367127 | 0.89 | ATM (0.51) | ATMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8638808 | 0.89 | ATM (0.51) | ATMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7367128 | 0.89 | ATM (0.51) | ATMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7425984 | 0.84 | ATM (0.46) | ATMSLC9A3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7420724 | 0.84 | ATM (0.46) | ATMSLC9A3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7375058 | 0.84 | KDM1A (0.46) | ATMSLC9A3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7375062 | 0.84 | KDM1A (0.46) | ATMSLC9A3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8635984 | 0.84 | KDM1A (0.46) | ATMSLC9A3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7763167 | 0.83 | ATM (0.55) | ATMCYP2D6SLC6A2SLC6A4GAA | |
| SCHEMBL8633998 | 0.80 | KDM1A (0.44) | ATMSLC9A3HPGDCYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773463-A | DECALCIFICATION OF BRAIN DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-06-30 | — | — | US | disclosed |
| EP-0711272-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004028-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |