Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367127 | 1.00 | ATM (0.51) | ATMALDH1A1L3MBTL1LMNANR1H4 | |
| SCHEMBL8638808 | 1.00 | ATM (0.51) | ATMALDH1A1L3MBTL1LMNANR1H4 | |
| SCHEMBL7373603 | 0.89 | ATM (0.55) | ATMALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8635972 | 0.88 | NPC1 (0.42) | L3MBTL1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7371529 | 0.88 | NPC1 (0.42) | L3MBTL1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7369920 | 0.88 | NPC1 (0.42) | L3MBTL1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8652153 | 0.82 | ATM (0.47) | ATMALDH1A1L3MBTL1LMNANR1H4 | |
| SCHEMBL7336636 | 0.82 | ATM (0.47) | ATMALDH1A1L3MBTL1LMNANR1H4 | |
| SCHEMBL7336632 | 0.82 | ATM (0.47) | ATMALDH1A1L3MBTL1LMNANR1H4 | |
| SCHEMBL7370200 | 0.81 | SLC6A2 (0.45) | ALDH1A1L3MBTL1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711272-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004028-A1 | INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |