Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 14/20 | 0.37 |
| ▸ | CDK8 | P49336 | 14/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 13/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377524 | 0.92 | WEE1 (0.37) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7367507 | 0.89 | AAK1 (0.37) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7290292 | 0.85 | AAK1 (0.40) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7374768 | 0.85 | CHUK (0.37) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7294332 | 0.84 | CCNC (0.37) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL7291526 | 0.82 | CCNC (0.40) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL7376992 | 0.81 | AAK1 (0.35) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7376611 | 0.81 | ALDH1A1 (0.38) | CDK8CDK19WEE1ABL1PDGFRB | |
| SCHEMBL7371406 | 0.81 | CCNC (0.37) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7374676 | 0.81 | ALDH1A1 (0.38) | WEE1ABL1PDGFRBSRCPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |