Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 4/20 | 0.32 |
| ▸ | CDK8 | P49336 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 2/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367507 | 0.92 | AAK1 (0.37) | AAK1POLBGAATSHRCCNC | |
| SCHEMBL7377524 | 0.89 | WEE1 (0.37) | AAK1CCNCCDK8KMT2AHASPIN | |
| SCHEMBL7299766 | 0.85 | AAK1 (0.38) | AAK1POLBGAATSHRCCNC | |
| SCHEMBL7373225 | 0.85 | CCNC (0.32) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7348684 | 0.84 | CCNC (0.31) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL7300200 | 0.82 | CCNC (0.33) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL8085352 | 0.81 | PDE4A (0.39) | RARARARBRARG | |
| SCHEMBL8090476 | 0.81 | SMN1; SMN2 (0.38) | GAAKMT2A | |
| SCHEMBL7373871 | 0.81 | AAK1 (0.37) | AAK1CCNCCDK8HASPINCDK19 | |
| SCHEMBL7372055 | 0.81 | GAA (0.38) | POLBGAATSHRMAPK10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |