Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364512 | 0.80 | EPHX2 (0.53) | SIGMAR1DRD4HRH3EPHX2 | |
| SCHEMBL19709002 | 0.78 | SIGMAR1 (0.63) | SIGMAR1HRH3HTR1ADRD2DRD1 | |
| SCHEMBL8327024 | 0.77 | DRD4 (0.65) | DRD4DRD2 | |
| SCHEMBL4228489 | 0.77 | DRD4 (0.65) | DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL19691895 | 0.77 | SIGMAR1 (0.64) | SIGMAR1HRH3HTR1ADRD2DRD1 | |
| SCHEMBL2798324 | 0.75 | DRD4 (0.58) | SIGMAR1DRD4HRH3HTR1ADRD2 | |
| SCHEMBL13840028 | 0.75 | DRD4 (0.52) | DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL30133733 | 0.74 | HTR4 (0.36) | SIGMAR1DRD4HRH3HTR1ADRD2 | |
| SCHEMBL4031016 | 0.72 | SIGMAR1 (0.51) | SIGMAR1DRD4 | |
| SCHEMBL21004110 | 0.72 | SIGMAR1 (0.84) | SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |