Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 15/20 | 0.72 |
| ▸ | MAOA | P21397 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3649253 | 0.88 | MRGPRX4 (0.76) | MAOBSMN1; SMN2MRGPRX4RAB9ATP53 | |
| SCHEMBL3646136 | 0.87 | RAB9A (0.65) | MAOBSMN1; SMN2MRGPRX4RAB9ATP53 | |
| SCHEMBL10892721 | 0.85 | MAOB (0.59) | MAOBMAOASMN1; SMN2MRGPRX4RAB9A | |
| SCHEMBL14547318 | 0.84 | MAOB (0.81) | MAOBSMN1; SMN2MRGPRX4RAB9ATP53 | |
| SCHEMBL9545816 | 0.84 | MAOB (1.00) | MAOBMAOASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6960292 | 0.83 | MRGPRX4 (0.72) | MAOBMAOASMN1; SMN2MRGPRX4RAB9A | |
| SCHEMBL933577 | 0.83 | MAOB (0.76) | MAOBMAOASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL22480782 | 0.82 | MRGPRX4 (0.76) | MAOBMAOASMN1; SMN2MRGPRX4RAB9A | |
| SCHEMBL2088282 | 0.82 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL9626622 | 0.82 | MAOB (0.65) | MAOBMAOASMN1; SMN2MRGPRX4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |