Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405885 | 0.89 | KMT2A (0.45) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7367287 | 0.88 | KMT2A (0.47) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL27514001 | 0.84 | KMT2A (0.44) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7684071 | 0.83 | MAPK8 (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7374580 | 0.83 | KMT2A (0.43) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7368614 | 0.74 | KMT2A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7369712 | 0.73 | MAPK8 (0.59) | KMT2A | |
| SCHEMBL5388867 | 0.72 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369264 | 0.72 | KMT2A (0.50) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL27535809 | 0.72 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |