Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27514001 | 0.95 | KMT2A (0.44) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7374580 | 0.94 | KMT2A (0.43) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7405885 | 0.93 | KMT2A (0.45) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7374248 | 0.88 | PDE4A (0.43) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7684071 | 0.86 | MAPK8 (0.49) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369264 | 0.83 | KMT2A (0.50) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7367980 | 0.78 | KMT2A (0.54) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16921584 | 0.76 | CTSS (0.49) | KMT2A | |
| SCHEMBL6906234 | 0.76 | MAPK8 (0.61) | KMT2A | |
| SCHEMBL27535809 | 0.75 | PDE4A (0.41) | KMT2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |