Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.44 |
| ▸ | PLG | P00747 | 4/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372432 | 0.86 | PLAU (0.54) | PLAUPLGPLATHSD11B1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7364720 | 0.82 | PLAU (0.41) | PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL7366996 | 0.81 | PLAU (0.42) | PLAUPLGPLAT | |
| SCHEMBL7369989 | 0.80 | PLAU (0.40) | PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL7368653 | 0.78 | PLAU (0.53) | PLAUPLGPLATHTTADAM17 | |
| Hydrochloric Acid SCHEMBL7366875 | 0.77 | PLAU (0.42) | PLAUPLGALDH1A1KDM4E | |
| SCHEMBL7380137 | 0.76 | PLAU (0.54) | PLAUPLGPLATHTTADAM17 | |
| Hydrochloric Acid SCHEMBL7378654 | 0.76 | PLAU (0.54) | PLAUPLGPLATHTTADAM17 | |
| SCHEMBL7366690 | 0.75 | PLAU (0.56) | PLAUPLGHTTNPSR1 | |
| SCHEMBL7369205 | 0.74 | PLAU (0.36) | PLAUPLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |