Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731595 | 0.82 | L3MBTL1 (0.67) | MCL1L3MBTL1TP53ALOX15HPGD | |
| SCHEMBL881471 | 0.81 | L3MBTL1 (0.70) | L3MBTL1TP53PARP10HPGDNPC1 | |
| SCHEMBL19520606 | 0.80 | HPGD (0.53) | PARP10HPGDNPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2280556 | 0.77 | TSHR (0.57) | MCL1L3MBTL1TP53ALOX15SMN1; SMN2 | |
| SCHEMBL29023726 | 0.77 | HDAC3 (0.47) | TP53PARP10ALDH1A1MEN1KMT2A | |
| SCHEMBL10591492 | 0.77 | MCL1 (0.46) | MCL1L3MBTL1TP53ALOX15HPGD | |
| SCHEMBL5075724 | 0.77 | HPGD (0.49) | MCL1L3MBTL1HPGDNPC1ALDH1A1 | |
| SCHEMBL5929477 | 0.76 | TP53 (0.52) | TP53ALOX15HPGDNPC1ALDH1A1 | |
| SCHEMBL11355811 | 0.76 | TP53 (0.46) | MCL1L3MBTL1TP53ALOX15HPGD | |
| SCHEMBL15048513 | 0.76 | L3MBTL1 (0.53) | MCL1L3MBTL1TP53ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |