Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398121 | 1.00 | KMT2A (0.54) | KMT2AMEN1ALDH1A1TP53MAPT | |
| Hydrochloric Acid SCHEMBL7447597 | 0.99 | KMT2A (0.53) | KMT2AMEN1ALDH1A1TP53MAPT | |
| SCHEMBL7459224 | 0.89 | KMT2A (0.45) | KMT2AMEN1ALDH1A1TP53MAPT | |
| SCHEMBL7459212 | 0.89 | KMT2A (0.45) | KMT2AMEN1ALDH1A1TP53MAPT | |
| SCHEMBL7377352 | 0.89 | KMT2A (0.45) | KMT2AMEN1ALDH1A1TP53MAPT | |
| Hydrochloric Acid SCHEMBL7403208 | 0.88 | KMT2A (0.44) | KMT2AMEN1ALDH1A1TP53MAPT | |
| Hydrochloric Acid SCHEMBL7403209 | 0.88 | KMT2A (0.44) | KMT2AMEN1ALDH1A1TP53MAPT | |
| SCHEMBL7374702 | 0.84 | LTA4H (0.53) | KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8396144 | 0.84 | LTA4H (0.53) | KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8396146 | 0.84 | LTA4H (0.53) | KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | claimed |
| EP-0752981-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-15 | — | — | EP | claimed |
| WO-1995026327-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-05 | — | — | WO | claimed |
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |