Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 17/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374702 | 1.00 | LTA4H (0.53) | LTA4HL3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8396144 | 1.00 | LTA4H (0.53) | LTA4HL3MBTL1KDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7457991 | 0.99 | LTA4H (0.52) | LTA4HL3MBTL1KDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7447607 | 0.84 | BCHE (0.41) | LTA4HL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7447605 | 0.84 | LTA4H (0.39) | LTA4H | |
| SCHEMBL7375422 | 0.84 | KMT2A (0.54) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8398121 | 0.84 | KMT2A (0.54) | KDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7447597 | 0.83 | KMT2A (0.53) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL22303073 | 0.82 | LTA4H (0.43) | LTA4HKMT2A | |
| SCHEMBL7375323 | 0.82 | HRH3 (0.48) | LTA4HMEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | claimed |
| US-5817698-A | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-10-06 | — | — | US | claimed |
| US-5817698-A | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-10-06 | — | — | US | disclosed |